How Using Gold Nanoparticles Develop Novel Nanosurgery Technique?

Nanotechnology in today’s society are more and more mature, the future development of new technologies provide a higher standard of living, the scientists are trying hard to explore new areas. A research team led by Professor Michel Meunier from the Polytechnique Montréal has developed a novel transfection technique using gold nanoparticles and a femtosecond laser to change cancer cells’ genetic material.

In this technique, silver nanoparticle and gold nanoparticles are deposited on the cells to concentrate the laser energy and enable it conduct a nano-scale surgery in a highly accurate non-invasive manner. This method is capable of changing the gene expression in the cancer cells to slow down their movement, thus preventing metastases formation. This pioneering achievement in nanosurgery paves the way to advance cancer treatments and other innovative medical applications.

This technique is a promising replacement for traditional cellular transfection techniques like lipofection. In the experiment on malignant human melanoma cells, this method showed an optoporation efficacy of 70% and a transfection performance three folds better than that of lipofection treatment. Moreover, contrary to traditional treatments that destroy the cells’ physical integrity, the novel technique ensures cellular viability with below 1% of toxicity.

This significant scientific advancement opens the door to develop promising applications such as novel therapeutic methods in cardiology, neurology, and oncology. The Polytechnique Montréal team works in partnership with scientists from the Department of Medicine at the McGill University Health Centre.

This project is funded by the Deutsche Forschungsgemeinschaft, the Canadian Institutes of Health Research, the Canada Research Chairs program, the Canada Foundation for Innovation, and the Fonds Québécois de la Recherche sur la Nature et les Technologies.

The research team has reported their findings in the journal Biomaterials.

Related reading: Silver Nanoparticles Antimicrobial aluminum oxide nanopowder


Does nd yag laser work and is it safe?

How does nd yag laser work and is it safe for patients?

Now, the nd yag laser machine provide very good result to remove different colot tattoo on body. The nd yag laser tattoo removal treatment is safe and effective, it will not affect other skin and it is also a non invasiave way to do tattoo removal.

Nd yag laser tattoo removal treatment use pluse of light from the laser handle to the tattoo, the laser energy will break up the tattoo pigment. The Q-Swithc nd yag laser machine is effective to dark tattoos, especially the black and blue. The laser tattoo removal treatment need 5-6 treatment to get a good result.

How Does the nd yag Laser Work?

The nd yag laser machine delivers light quickly with very high energy. These enegy will be absorbed by the tattoo, and break up the pigment.

Is Laser Tattoo Removal Safe?

Yes, the q switch nd yag laser technology is very safe and low risk with very little side effects.

What Kind of Tattoos Can Be Removed?

It can remove different types of tattoo. Such as traumatic tattoos, resulting from accidents, are treated successfully.

The q switch laser machine ca removar all color tattoo?

The Q-switch nd yag laser machine is effective to the dark,blue tattoos. It also have result for other color.

Weifang KM is a professional laser beauty machine supplier in China more than 9 years.

The Q-switch nd yag laser machine is very popular in Europe and USA countries.

Following is our nd yag laser machine advantage:

1. With new nd yag laser handle, the energy output is much higher

2. No need to debug, no light leakage

3. Lower than 1‰ maintenance and much longer life time.

4. Accurate treatment, no hurt normal tissue

5. Without down time, no effect busy lifestyle

6. Significant performance without side effects

7. Accurate energy output, to meet the ideal effect by safe operating environment.

8. Advanced integrated cooling system with water & air & semiconductor

9. Module design, easier to check, upgrade and maintenance

10. 8 inch intelligent touch screen, easier and friendly to operate for users

More information at

Applications of d-Mannose

Mannose, packaged as the nutritional supplement “D-mannose“, is a sugar monomer of the aldohexose series of carbohydrates. Mannose is a C-2 epimer of glucose. Mannose is important in human metabolism, especially in the glycosylation of certain proteins.
Applications of d-Mannose
Novel sugars were expected as alternative sweeteners to sucrose, because of their sweet-taste and low calories. Till now, the uses of d-mannose is limited and just used as a dietary supplement for direct consumption. As shown in Table 5, the current top-selling brands of d-mannose include NOW Foods, Source Naturals, and Vibrant Health. Most products are distributed in the form of capsules or powders containing plant-based d-mannose. Moreover, some features of d-mannose could improve food texture, such as its solubility and anti-melting capability. Because of these special properties, d-mannose has been commercially used in the food industry. d-Mannose has been added to commercially ice-cream, processed fruits, and salad dressings to improve texture (Sutton and Wilcox 1998). Among the sugar analogs tested, d-mannose has some effects in controlling decay in inoculated apple and peach fruit, which can slightly reduce lesion diameter (Elghaouth and others 1995). Takao and others (2008) presented a mannose-based compound comprised of 1 to 10 molecules of d-mannose, which could effectively reduce blood pressure and/or suppress blood pressure elevation without changing ordinary eating habits when applied in food.
Besides the above-mentioned d-mannose physiological function used in the treatment of corresponding diseases, d-mannose is used as an inexpensive starting material for the synthesis of immunostimulatory agents (Ranta and others 2012), antitumor agents (Kamel and others 2010), vitamins (Chen and others 2007), and d-mannitol (Mishra and Hwang 2013). The global market for mannitol is estimated to have annual sales of approximately $100 million. Currently, the biotransformation of mannitol from d-mannose is becoming a new production trend for mannitol. Reduction of d-mannose with sodium borohydride or electrolysis leads to a high d-mannitol yield of over 31% (Ghoreishi and Shahrestani 2009). d-Mannitol is used in the production of drug delivery systems (Chen and others 2005) and in the synthesis of medicines such as oseltamivir phosphate (Chuanopparat and others 2012) and new drugs against AIDS (Botos and others 2002). Moreover, the addition of d-mannose to the natural cytotoxic cell assay significantly blocked cytotoxicity of the fibrosarcoma Meth A target by the effector cells at 50 mM and lower concentrations. In the natural cytotoxic system, recognition involved lectin-like structures with specificity for d-mannose. D-mannose also inhibited natural kill (NK) cell lysis of the lymphoma YAC-1 target, whereas in the NK system such lectin-like structures were less restricted (Stutman and others 1980). Peri-spinal treatment with d-mannose may optimize naked pDNA-IL-10 transgene uptake for suppression of allodynia, and is a novel approach to tune spinal immune cells toward pro-phagocytic phenotype for improved non-viral gene therapy (Dengler and others 2014).
Aloe vera is good for health and beauty, and its function is closely correlated with the presence of mannose-rich polysaccharides (Eshun and He 2004). Similarly to d-glucose, d-fructose, d-ribose, and d-xylose, d-mannose is an auxiliary moisturizing agent that is widely used in skin-care products. The d-mannose units are linked to each other by β(1-4) glycosidic linkages. d-Mannose exhibits excellent moisturizing and skin feel capabilities, and leaves the skin less taut, less dry, and more moisturized (Schmidt and others 1991). Deckner and Wivell (1997) patented a product featuring components that provide both skin-cleansing and skin-moisturizing benefits. The product contains d-glucose, d-mannose, and d-glucuronate in a molar ratio of 2.8:2.0:2.0.Feed additives
Over the past several decades, antibiotics have been widely used in animal agriculture and have displayed therapeutic effects against disease to improve growth performance (Witte 1998). However, now antibiotics have come under increasing scrutiny because of the potential development of antibiotic-resistant human pathogenic bacteria after their long-term use (Allen and others 2013; Cully 2014). Indeed, there is growing concern over the transmission of resistant bacteria via the food chain (Santin and others 2001). People have begun to look for other ways to replace antibiotics as feed additives. d-Mannose could strongly inhibit the attachment of S. typhimurium to intestinal cells of day-old chickens in vitro and offer a competitive binding site for a certain class of bacteria (Oyofo and others 1989). Moreover, mannan-oligosaccharides may be used as alternative antibiotics to improve turkey health (Parks and others2001). A commercial product available for poultry contains yeast cell wall fragments derived from Saccharomyces cerevisiae after centrifugation of a lysed yeast culture, because the cell wall of yeast contains a large amount of mannans (Van Immerseel and others 2002). For now, d-mannose is the most effective sugar at blocking colonization and is used extensively in animal feeds to inhibit the growth of intestinal pathogens (Berge and Wierup 2012; Galis and others 2013).
Other applications
In modern scientific research, d-mannose plays an increasing significant role in various areas. d-Mannose can be used as a carbohydrate source in a synthetic medium or as a constituent of chemically defined media for cell culture (Wang and others 2000). In transgenic technology, scientists have used d-mannose as a marker that has enabled plant cells to grow and form new plants. d-Mannose could be an alternative to antibiotic resistance genes as markers in future transgenic crops. To date, hundreds of primary transgenic rice plants of different cultivars have been obtained from mannose-resistant cells (Datta and others 2003).
In conclusion, d-mannose is a common sugar existing in various foods. Because of its diversified properties, d-mannose has attracted increasing attention from the food industry and academia. This review of literature has revealed that d-mannose, as a highly potential functional and valuable ingredient, exhibits relatively impressive biological functions of great interest in the cosmetic, pharmaceutical, and food industries. The use of chemical methods in the production of d-mannose has the advantages of applying rapid and convenient processes, but some consumers do not agree with the production by chemical methods. Thus, with ongoing efforts in research and development, the biotransformation approach to d-mannose production with enzymes has gradually gained increasing interest and has become the most promising method. The results of a comparison of bio-enzymes suggest that MIases are promising enzymes for d-mannose biosynthesis; however, from a previous study, the conversion rates of reported MIases from d-fructose are inadequate (15 to 35%), and it is suggested that the exploration of novel enzymes with high conversion efficiency can significantly promote the production of d-mannose. In addition, further research is needed to evaluate the efficacy and long-term safety of d-mannose, especially focusing on its performance in food systems.Related reading:D-mannose Cas 3458-28-4    D-galactose NAD

4 tips when installing new amusement game machine in your game center

Installation of new game machines is very important after buying them,and some skills are necessary during the installation which requires professionals.What should we pay attention to when installing kids game machines?

More and more kids will go to kids game center for fun nowadays.Usually Owners check machines everyday and players take care of the dos and don’ts to avoid accidents,but actually there are many matters we need to pay attention to while installation before operation.

What problems we should pay attention to while install kids game machines?

1.During installation,all sharp corners,protuberances are prohibited in all touchable positions,decorations on machines must be fixed firmly.

2.Notices such as instructions and dos and don’ts on machines are necessary.Put them in conspicuous position,players will measure if they are available or not.

3.While installation,do not put the huge machines directly on floor for less bother.Must fix the machine on floor or fix them with tools to avoid collapse accidents.

4.Game machines installation must follow the manual from supplier instead of using own methods.To avoid the situation that all kinds of problems occurs after using period of time while it looks good surfacely.All operators must try to install and debug machines at first,in order to avoid various of problems in the future.

For outsource installation,complete quality documents of manufacture and installation should be offered.For manufacturer and installation from one same supplier,final quality documents could offer just one file but include both certificates of manufacture and installation.

If you are interested in crane machine, kiddie rides and other amusement game machines, please visit our website ( for more information.

Related reading:indoor basketball game  coin operated game machine

What are the current problems of the crane machine operation?

1-Hard to change for coin to play
When customers don’t has coins or just finish the coins at hand,they have to find a coin changing machine or use online payment.For the owner,it not only increase the cost of coin changing machine but also takes a lot of time to count the coins and bills.

2-Insufficient innovation of play mode.
At the moment most crane game machine use the traditional joystick method to play and customers find it less interesting.So some innovation machines with different play mode like “Crazy scissors”,”Push&Win” are more interesting to customers.

3-The lack of confidence of customer.
After it becomes a public secret that the winning ratio can be set in advance,customers have less confidence in crane machine now.

4-Low quality toys.
What really attract customers to play is the toys inside.However,a lot of toys are copys with low quality,unfeatured appearance.It it hard to draw people’s attention when they are passing by the cranes.

5-Old design cabinet.
Many cranes in the market are the ones with dated design and dim color and there are too many same designs.It is hard to distinguish your cranes with others and customers won’t come to play again.

In the next artical we will discuss about how to solve these problems.

If you are interested in crane machine, kiddie rides and other amusement game machines, please

visit our website ( for more information.

Related reading:toy crane machine arcade crane machine

LOPO Project-Changsha Normal University Use Terracotta Architectural Panels

Changsha Normal University belongs to public colleges, the school history can be traced back to 1912 by the famous educator Xu Te Li founded the Changsha County Normal School, It was formally upgrade from college to university in April 2013, named Changsha Normal University. The school has two campuses with south and north, the area more than 1100 acres, construction area of 328,400 square meters.

Changsha Normal University with orange as the main color, orange on behalf of vitality, sunshine, vibrant lively, and students period is very consistent. The design use of lotus form as a source of inspiration, through the curve of the drawing highlights the shape of pre-flying pigeons. Meaning the wings of the students, and humanitarian teaching the nature of the school.

The architectural designers have selected LOPO terracotta architectural panels 450mm wide and 18mm thick. These panels combine vertically and horizontal installed to extend the vertical lines of low-rise buildings.


Item No.:F2030562/F6030528

Welcome to contact us for your own customized terracotta rainscreen panels.

Related reading: Terracotta Panel LOPO Terracotta

The Necessity Of Building Sponge City – Rainwater Harvesting Module

The sponge city means city can soaked up water like sponge. This kind of city would be able to maximize retain of rainwater. Specifically, it is provided a plurality of plots in the city district, with the construction of absorbent material, as a sponge, when the time of rainstorm, it become a water storage place.Whether it is the mud, grass, tree or lakes absorb a lot of rain. In this way, the water can be digested, avoid the flooding. When those rain be absorb by the sponge, The problem of water accumulation has also been alleviated.

The amount of rainwater can be used again, such as landscaping irrigation, garden water, toilet flushing, car washing, can alleviate the shortage of water resources situation in a certain extent.

Speaking of the sponge city, what I have to mention is Rainwater Harvesting Module, as the heart part of sponge city, Leiyuan GS-TANKs is devoted to Rainwater harvesting tank’s research and development. By this time, has developed into fifth generation- M2016S tank and M2016B tank.

M2016 series, Uniquely using the hollow circular column as the key supporting point, not only maximized the specificstorage, but also enhance the bearing capacity to 45T/sqm. Structure more simple, transportation and installation more convenient.

More products detail please visit

Related reading: Rainwater harvesting tank Rain Water Harvesting Modular